Name | YTTRIUM NITRATE HEXAHYDRATE |
Synonyms | yttriumnitrat YTTRIUM NITRATE HEXAHYDRATE yttriumtrinitratehexahydrate Nitricacid,yttrium(3+)salt,hexahydrate |
CAS | 13494-98-9 |
EINECS | 677-716-0 |
Molecular Formula | H12N3O15Y |
Molar Mass | 383.01 |
Density | 2.682 g/mL at 25 °C(lit.) |
Melting Point | 51.8°C |
Water Solubility | Soluble in water. |
Appearance | Form Solid, color White |
PH | 3.5 (50g/l, H2O, 20℃) |
Storage Condition | 0-6°C |
Use | Use of scientific research reagents, biochemical research. As a yttrium source, it is used to make yttrium-based surfactant mesophase, which can be used as adsorbent or for optical functional substances. Precursors for Nano-scale Coatings of Carbon Composites |
Risk Codes | R8 - Contact with combustible material may cause fire R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S17 - Keep away from combustible material. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
UN IDs | UN 1477 5.1/PG 3 |
WGK Germany | 3 |
RTECS | ZG3750000 |
TSCA | Yes |
HS Code | 2846 90 20 |
Hazard Class | 5.1 |
Packing Group | III |
Toxicity | LD50 orally in Rabbit: 3890 mg/kg |
Downstream Products | YTTRIUM FLUORIDE |
Sensitivity | Hygroscopic |
Merck | 14,10107 |
Synthesis
Yttrium nitrate is obtained by dissolving a slightly excess yttrium oxide in concentrated nitric acid under heating. Burn yttrium oxide at 900 ℃ for 3 hours, and dissolve it in a 1:1 nitric acid solution after cooling. The PH of the solution at the end of the reaction was controlled to be 3-4. Distill the solution under reduced pressure into a syrup, and slowly crystallize at room temperature. Recrystallization twice. In the last recrystallization, a small amount of yttrium nitrate needs to be added as a seed to obtain yttrium nitrate hexahydrate.
Toxicity
1. nephrotoxicity: some experiments have studied the effect of yttrium nitrate on the kidney of growth and development rats. the experiments are divided into four groups: 0, 20, 80 and 320 ppm (based on yttrium in feed). the offspring rats are continuously exposed from GD0 to PND70. the kidneys of 20 offspring rats (half male and half female) in each group are taken to detect changes in antioxidant enzyme activity, miRs expression level, renal histopathology and KIM-1 antigen expression level. The results showed that compared with the control group, the miR-18a-5p and miR-21-3p of female mice were lower in 320 ppm group. The miR-18a-3p of male mice decreased in 20 ppm group, increased in 320 ppm group, and increased in 320 ppm group. GSH-Px activity increased in 80 ppm group, GSH-Px activity decreased in 320ppm group, and GST activity decreased in 320 ppm group. The expression level of KIM-1 in 320 ppm group of female and male mice increased. Therefore, when GD0 to PND70 yttrium nitrate is exposed, the renal antioxidant capacity of rats in 320 ppm group is reduced, which affects the expression level of miRs and KIM-1, suggesting that yttrium nitrate exposure in early life may affect renal function by reducing antioxidant capacity.
2. Neurotoxicity: using the membrane island-transferrin-selenium-fibronectin (ITSFn) model to study the possible mechanism of the neurodevelopmental effects of yttrium nitrate. The results show that high concentration of yttrium nitrate can increase the growth inhibition rate and apoptosis rate of neuronal cells, suggesting that cell apoptosis is one of the mechanisms of the effect of yttrium nitrate on neural development. Low concentration of yttrium nitrate can promote the expression of anti-apoptosis gene Bcl-2 in neuronal cells, but inhibit the expression of anti-apoptosis gene Bcl and Caspase-3, and play a role in protecting cells; but when the yttrium nitrate solution reaches a certain concentration It will activate the expression of Bcl and Caspase-3, down-regulate the expression of Bcl-2, thereby inducing cell apoptosis. The Bcl-2/Bax ratio also shows a trend of rising first and then falling. It shows that the effect of yttrium nitrate on neural development of mouse embryonic stem cells is dose-dependent, 0.55 μg/ml-27.5μg/ml completely covers the dose range from low dose of yttrium nitrate to high dose of toxicity.
Solubility in water (g/100ml)
Dissolved grams per 100 ml of water at different temperatures (℃):
93.1g/0℃;106g/10℃;123g/20℃;143g/30℃;163g/40℃
200g/60℃
Production method
The slightly excess Y2O3 is reacted with hot concentrated nitric acid. After the reaction, the unreacted oxide is filtered to remove, crystallized, sucked and filtered, and dried to obtain the product.